Endocrine Abstracts

Aldosterone play pivotal roles on renal fibrosis by inducing mesangial cells proliferation and stimulating collagen synthesis in renal fibroblasts. However, whether renal proximal tubules are involved in aldosterone-induced renal fibrosis is not yet identified. The aim of this study was to examine the potential role of aldosterone in collagen expression via activation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) in cultured human renal proximal tubular epit...

Adrenocortical carcinoma (ACC) is a rare endocrine tumour with a generally poor prognosis. Mitotane is the only approved drug for treatment of advanced ACC (“palliative” setting). However, response is relatively poor with up to 20% of patients experiencing objective response (Megerle 2018). Moreover, adjuvant treatment with mitotane is frequently recommended for patients at high risk of disease recurrence after surgery (Terzolo 2007, Fassnacht 2018). Of note, mitotan...

Introduction: Progressive osseous heteroplasia (POH) is a rare genetic condition of progressive heterotopic ossification (HO), from skin and subcutaneous tissues into deep skeletal muscles. Most cases are caused by heterozygous inactivating mutations of GNAS gene. Related disorders are Albright hereditary osteodystrophy (AHO), pseudohypoparathyroidism (PHP), and primary osteoma cutis. Distinction from other GNAS-based conditions is made by the extension of HO from superficial ...

There are two issues: i) dopamine agonist (DA) safety for mother and baby, and ii) risk of oestrogen-induced prolactinoma enlargement. Bromocriptine (BC) and Cabergoline (CAB) are both safe for ovulation induction but the safety database is larger for BC (6239 pregnancies) than for CAB (789). Neither drug causes increases in miscarriage, premature delivery, multiple births or congenital malformations, compared to data for normal pregnancy. Risk of symptomatic tumour enlargemen...

A 27-year-old woman presented with a 6-week history of weight loss, excessive thirst, nocturia and lethargy. She had no significant past medical or family history. At presentation she was unwell, tachycardic and had a blood pressure of 174/100 mm Hg. Physical examination was otherwise unremarkable. Her urine dipstick was strongly positive for glucose and ketones. The plasma glucose was 21.7 mmols/l. An arterial blood gas showed a pH of 7.35 and bicarbonates of 23. She was trea...

The hypoglycaemic effect of Syzygium (i) cordatum (i) leaf extract was studied in non-diabetic and streptozotocin (STZ)-induced diabetic rats. The crude was subjected to column chromatography and spectroscopic analysis. Non-diabetic and STZ-diabetic rats were orally administered glucose (1.4 g.100 kg-1 (super -1) body weight) followed by extract (6 mg.100-1g (super -1) body weight). Weekly plasma glucose and terminal hepatic glycogen concentrations were recorded in control STZ...

Objectives: We assessed the implications of PINP (procollagen type I N-terminal propeptide), NTX (cross-linked N-telopeptides of type I collagen), E2 (estradiol), calcium (Ca2+), phosphorus (PHOS(2−)), and their correlation with bone mineral density (BMD) in the process of bone remodeling of postmenopausal osteoporosis.Methods: The study was performed on two groups of women with postmenopausal osteoporosis (with different degr...

Introduction: The risk association between the insulin like growth factor-1 (IGF1) and cardiovascular risk is inconclusive in adults and under-explored in the pediatric population. We aimed to investigate the associations between serum concentrations of IGF1 and cardiovascular risk factors in obese children and adolescents.Methods: Cross-sectional study. Clinical and metabolic evaluations including an oral glucose tolerance test (OGTT) were performed at ...

Objectives: There are some reports about association of autoimmune thyroid diseases with human T cell leukemia virus type I (HTLV-I) infection. The objective of this study was to estimate the seroprevalence rates of anti-thyroid antibodies in HTLV-I carriers and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients in Mashhad, north east of Iran, to determine any association between HTLV-I infection and Hashimoto’s thyroiditis (HT).<p class="abs...

Background: Serum IGF-I and IGFBP-3 levels respectively have a positive and negative association with subsequent risk of breast cancer. The anti-oestrogen tamoxifen is widely used as adjunctive therapy after resection of primary breast tumours. Tamoxifen has been reported to influence serum IGF-I, although its effects on BP-3 are unknown. The effects of tumour resection itself on IGF-I and BP-3 levels are unclear.Aims: To determine the effects of surgery...